4. Webb Drugstore (1852)

409 E. 13th Street
This commercial building was originally two adjoining stores built by retired sea captains John Webb and Henry Miller. The drugstore was the first and for many years, the only drugstore in Brownsville. John Webb also operated a stagecoach line and helped draft the application to the Texas Legislature for the incorporation of the City of Brownsville. The building underwent an extensive restoration and currently houses the art gallery, "Galeria 409."